The NMN (nicotinamide mononucleotide) is an extremely studied and sought-after substances to slow the process of aging.
NMN is a chemical that naturally occurs in our body.
NMN is the precursor for NAD+. NAD+ is an vital molecule that is found in every cell within our body.
NAD+ is an ingredient that many proteins and enzymes must use to fulfill their job.
For instance, NAD+ is required to ensure proper repair and maintenance of our epigenome and DNA (by enzymes such as sirtuins or PARPs).
What are the consequences of NMN?
1. NMN boosts the energy levels
Many times, people say they are more energetic after they consume NMN.
For a boost in energy levels, you should get a dose that is sufficient.
There are people who have experienced an effect after taking the dose of 250 mg of NMN supplements however, others require at minimum 500 mg.
Studies have shown that when administered orally NMN improves endurance and stamina in mice who are old, by as much as 80 percent.
2. NMN increases memory
The majority of people who utilize NMN have improved cognitive performance, which makes users feel sharper and better at concentrating.
There are also studies that show that NMN can have beneficial effects on brain function, such as improving the brain’s cognition as well as blood flow to the mice’s brains.
The brain’s blood flow is restored in older mice that take NMN at the same levels that young mice. The mice that are red have no NMN.
Source: Nicotinamide Mononucleotide (NMN) supplementation helps to restore neurovascular and cerebromicrovascular coupling reactions and enhances cognition in older mice. Redox Biology, 2019
3. NMN & healthier blood vessels
Research has shown that NMN revitalizes the blood vessels of old age. NMN greatly enhances, for instance the elasticity of vascular blood vessels in older animals.
Old mice who are given NMN contain blood vessels that expand just as much as young control mice and mice that receive NMN. The dilation of blood vessels was greatly diminished in mice of old age who did not receive NMN.
Source Nicotinamide Mononucleotide Supplementation helps to reverse the effects of oxidative stress and vascular dysfunction when mice get older. Aging Cell, 2016
Additionally, mitochondria in those cells which line blood vessels (endothelial cells) remain healthier when NMN is used. Mitochondria are the energy sources of cells.
4. NMN increases metabolism
This is crucial as the metabolism is reduced dramatically and can lead to an increase in chance of developing many illnesses.
Studies have shown that NMN can decrease insulin resistance, enhance the lipid profile of plasma and help reduce the weight gain associated with aging gain, while simultaneously enhancing physical exercise.
5. NMN helps reverse decline due to aging in the elderly
As we age there are many things that decline including our eyesight endurance, stamina levels as well as bone density, energy levels and immune system. These all improve as per studies on mice that are old.
6. NMN improves fertility
A few people who use NMN claim to experience an increase in the amount of libido.
Biotech companies have found the fact that NMN or NMN derivatives can help make animals that are old fertile.
7. NMN helps improve the health of stem cells
When we age, stem cells diminish in number, and stem cells tend to become deficient. This causes aging because stem cells create new cells, and they maintain our tissues. Numerous studies have shown that NMN and increasing NAD levels, can help improve the health of stem cells and improve self-renewal.
8. NMN repairs DNA damage
NMN assists cells in repairing damaged DNA. DNA damage is among the reasons that we become older.
Mice who received NMN showed significantly less DNA damage (as determined by alpha-H2AX an indicator of DNA damages).
Numerous other studies have shown beneficial effects of NMN in reducing aging and in some cases, reverse age-related conditions in older animals back to a healthier condition.
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